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영남의대학술지 Vol.28 No.1 p54-59, June2011
Case Report
횡문근융해증에 의한 급성 신 손상이 동반된 렙토스피라증 1예
Rhabdomyolysis Induced Acute Kidney Injury in a Patient with Leptospirosis
최윤정, 박정민, 정요한, 남종호, 정현희, 김태우1, 조규향, 도준영, 윤경우, 박종원
영남대학교 의과대학 내과학교실, 순천향대학교 구미병원1
교신저자：박종원, 대구광역시 남구 대명5동 317-1, 영남대학교 의과대학 내과학교실
Tel: (053) 620-3849, Fax: (053) 654- 8386
E-mail : jwpark@med.yu.ac.kr
June 30, 2011
Abstract
Leptospirosis is a spirochetal infectious disease caused by Leptospira interrogans, and may vary in degree from an asymptomatic infection to a severe and fatal illness. The kidney is one of the principal target organs of Leptospira. Renal disorders caused by Leptospira infection vary from an abnormality in urinalysis to acute kidney injury (AKI). Incidence of AKI in severe leptospirosis varies from 40% to 60%. AKI reflects the severity of leptospirosis and is generally accompanied by cholestatic jaundice. The pathophysiology of AKI in leptospirosis consists of hypovolemia, direct tubular toxicity, and rhabdomyolysis. Most patients with acute leptospirosis experience severe myalgias, and show laboratory evidence of mild rhabdomyolysis. However, occurrence of severe rhabdomyolysis is rare. We report here on a patient with leoptospirosis, who had severe rhabdomyolysis and acute kidney injury without jaundice.
Key Words: Leptospirosis, Acute renal failure, Rhabdomyolysis
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